Ginsenoside CK inhibits androgenetic alopecia by regulating Wnt/β‐catenin and p53 signaling pathways in AGA mice

نویسندگان

چکیده

Androgenetic alopecia (AGA) is one of the most common chronic skin diseases caused by destruction androgens in body. It excessive deposition dihydrotestosterone around hair follicle, resulting follicle atrophy and cell apoptosis. causes great anxiety psychological distress to patients affects sexual function severe cases. As traditional Chinese herbs, ginsenosides have been proven possess various pharmacological activities. Ginsenoside CK main ginsenosides, but its role molecular mechanism treating AGA remain unclear. Here, we found that ginsenoside intervention significantly reduced back loss mice, improved organ damage apoptosis, promoted growth mice. treatment inhibited p53 expression, apoptosis cells induced hormone deposition, activated Wnt/β-catenin proliferation signaling pathway, increased level vascular endothelial factor, proliferation, tissue. also testosterone levels testicular tissue inflammation, restored normal metabolism Our results indicated development, prolonged cycle regulating Wnt pathways, indicating potential value as a natural therapeutic agent for AGA.

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ژورنال

عنوان ژورنال: Food frontiers

سال: 2023

ISSN: ['2643-8429']

DOI: https://doi.org/10.1002/fft2.272