Ginsenoside CK inhibits androgenetic alopecia by regulating Wnt/β‐catenin and p53 signaling pathways in AGA mice
نویسندگان
چکیده
Androgenetic alopecia (AGA) is one of the most common chronic skin diseases caused by destruction androgens in body. It excessive deposition dihydrotestosterone around hair follicle, resulting follicle atrophy and cell apoptosis. causes great anxiety psychological distress to patients affects sexual function severe cases. As traditional Chinese herbs, ginsenosides have been proven possess various pharmacological activities. Ginsenoside CK main ginsenosides, but its role molecular mechanism treating AGA remain unclear. Here, we found that ginsenoside intervention significantly reduced back loss mice, improved organ damage apoptosis, promoted growth mice. treatment inhibited p53 expression, apoptosis cells induced hormone deposition, activated Wnt/β-catenin proliferation signaling pathway, increased level vascular endothelial factor, proliferation, tissue. also testosterone levels testicular tissue inflammation, restored normal metabolism Our results indicated development, prolonged cycle regulating Wnt pathways, indicating potential value as a natural therapeutic agent for AGA.
منابع مشابه
Title: Association of Premature Androgenetic Alopecia and Metabolic Syndrome in a Young Indian Population ABSTRACT Context: Although evidences for association of androgenetic alopecia (AGA) with metabolic syndrome
Materials and Methods: The Norwood–Hamilton classification was used to assess the grade of AGA. MetS was defined according to the National Cholesterol Education Program Adult TreatmentPanel III criteria. Blood pressure, blood glucose, lipid parameters, and body mass index along with anthropometric measurements were assessed in all study participants. Statistical Analysis Used: Chi ‐square test ...
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ژورنال
عنوان ژورنال: Food frontiers
سال: 2023
ISSN: ['2643-8429']
DOI: https://doi.org/10.1002/fft2.272